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Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease

✍ Scribed by O. A. Buneeva; A. E. Medvedev

Book ID
110153653
Publisher
Springer
Year
2006
Tongue
English
Weight
202 KB
Volume
71
Category
Article
ISSN
0006-2979

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## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic