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Role of Ionic Fluxes in the Apoptotic Cell Death of Cultured Cerebellar Granule Neurons

✍ Scribed by A. Franco-Cea; A. Valencia; S. Sánchez-Armass; G. Domínguez; J. Morán

Book ID
111602203
Publisher
Springer
Year
2004
Tongue
English
Weight
224 KB
Volume
29
Category
Article
ISSN
0364-3190

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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300