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Role of Cytoskeleton Proteins in the Morphological Changes During Apoptotic Cell Death of Cerebellar Granule Neurons

✍ Scribed by Alette Ortega; Julio Morán

Publisher
Springer
Year
2010
Tongue
English
Weight
972 KB
Volume
36
Category
Article
ISSN
0364-3190

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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300