## Abstract Neuronal apoptotic death involves the participation of reactive oxygen species (ROS), but their sources have not been completely elucidated. Previous studies have demonstrated that the ROS‐producing enzyme NADPH oxidase is present in neuronal cells and that this enzyme could participate
Oxidation of Biomolecules in the Apoptotic Death of Cerebellar Granule Neurons Induced by Potassium Deprivation
✍ Scribed by Juan M. Hernández-Martínez; Guadalupe Domínguez; Sugela Blancas; Julio Morán
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 498 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0364-3190
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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300
## Abstract Several neurotrophic factors, including brain‐derived neurotrophic factor (BDNF), and neurotransmitters, such as glutamate, may influence neuronal apoptotic death. Rat cerebellar granule neurons (CGN) cultured in low potassium (5 or 10 mM KCl) for more than 5 days in vitro (DIV) die apo
## Abstract During the excitotoxic neuronal cell death which accompanies an overflow of extracellular Ca^2+^ into neurons, aconitase, an oxidative stress‐sensitive enzyme of the tricarboxylic acid (TCA)‐cycle in mitochondria, is inactivated due to the generation of oxidative stress (Patel et al. [1