AMPA Neurotoxicity in Cultured Cerebellar Granule Neurons: Mode of Cell Death
β Scribed by Gvido Cebers; Boris Zhivotovsky; Maria Ankarcrona; Sture Liljequist
- Book ID
- 117502476
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 773 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0361-9230
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π SIMILAR VOLUMES
## Abstract Cultured rat cerebellar granule neurons exposed to solutions of reduced osmolarity, responded initially by swelling followed by a regulatory volume decrease (RVD) which is completed within 15 min. Increasing external osmolarity lead to cell shrinking but no evidence of volume regulation
When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300