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Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons

✍ Scribed by Jing-Yu Yang; Kazuho Abe; Nan-Jie Xu; Norio Matsuki; Chun-Fu Wu


Book ID
117472875
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
172 KB
Volume
328
Category
Article
ISSN
0304-3940

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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300