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Redox regulation of the tumor suppressor PTEN by glutathione

✍ Scribed by Yujeong Kim; Yong Bhum Song; Tae-Youl Kim; Inyoung Kim; Seong-Jeong Han; Younghee Ahn; Seung-Hyun Cho; Cheol Yong Choi; Kee-Oh Chay; Sung Yeul Yang; Bong Whan Ahn; Won-Ki Huh; Seung-Rock Lee

Book ID: 113622114
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 814 KB
Volume: 584
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.07.006

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PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell d