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DJ-1, a novel regulator of the tumor suppressor PTEN

✍ Scribed by Raymond H. Kim; Malte Peters; YingJu Jang; Wei Shi; Melania Pintilie; Graham C. Fletcher; Carmela DeLuca; Jennifer Liepa; Lily Zhou; Bryan Snow; Richard C. Binari; Armen S. Manoukian; Mark R. Bray; Fei-Fei Liu; Ming-Sound Tsao; Tak W. Mak

Book ID: 113523538
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 623 KB
Volume: 7
Category: Article
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2005.02.010

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PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell d