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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

✍ Scribed by Vuk Stambolic; Akira Suzuki; José Luis de la Pompa; Greg M Brothers; Christine Mirtsos; Takehiko Sasaki; Jurgen Ruland; Josef M Penninger; David P Siderovski; Tak W Mak


Book ID
117268522
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
998 KB
Volume
95
Category
Article
ISSN
0092-8674

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Negative Regulation of PKB/Akt-Dependent
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PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell d

Protein kinase B (PKB/Akt) activity is e
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