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Presenilins regulate the cellular level of the tumor suppressor PTEN

โœ Scribed by Han Zhang; Runzhong Liu; Ruishan Wang; Shuigen Hong; Huaxi Xu; Yun-wu Zhang

Book ID
116781060
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
842 KB
Volume
29
Category
Article
ISSN
0197-4580

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PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell d