𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

✍ Scribed by Nugent, Richard A.; Schlachter, Stephen T.; Murphy, Michael J.; Cleek, Gary J.; Poel, Toni J.; Wishka, Donn G.; Graber, David R.; Yagi, Yoshihiko; Keiser, Barbara J.; Olmsted, Robert A.; Kopta, Laurie A.; Swaney, Steven M.; Poppe, Susan M.; Morris, Joel; Tarpley, W. Gary; Thomas, Richard C.


Book ID
120259459
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
189 KB
Volume
41
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


ChemInform Abstract: Pyrimidine Thioethe
✍ R. A. NUGENT; ET AL. ET AL. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito