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ChemInform Abstract: Stereoselective Synthesis of Furo[2,3-c]pyridine Pyrimidine Thioethers, a New Class of Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

✍ Scribed by Donn G. Wishka; David R. Graber; Eric P. Seest; Lester A. Dolak; Fusen Han; William Watt; Joel Morris


Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
30
Category
Article
ISSN
0931-7597

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The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito

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