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ChemInform Abstract: Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV.

✍ Scribed by R. A. NUGENT; ET AL. ET AL.

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199911171

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✦ Synopsis

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibitory activities against wild type and P236L RT, but only derivatives (IIb) and (IIc) retain good activity against the laboratory-derived DLV-resistant variant of HIV-1 M F . -(NUGENT, R. A.

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