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ChemInform Abstract: 1-Arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles, a Novel Class of anti-HIV-1 Reverse Transcriptase Inhibitors.

✍ Scribed by M. ARTICO; R. DI SANTO; R. COSTI; S. MASSA; F. SCINTU; A. G. LOI; A. DE MONTIS; P. LA COLLA


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Pyrimidine Thioethe
✍ R. A. NUGENT; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito