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Etravirine: A second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV

✍ Scribed by Daryl S. Schiller; Manal Youssef-Bessler


Book ID
113543969
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
155 KB
Volume
31
Category
Article
ISSN
0149-2918

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ChemInform Abstract: Pyrimidine Thioethe
✍ R. A. NUGENT; ET AL. ET AL. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito