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Novel 8-Substituted Dipyridodiazepinone Inhibitors with a Broad-Spectrum of Activity against HIV-1 Strains Resistant to Non-nucleoside Reverse Transcriptase Inhibitors

✍ Scribed by O'Meara, Jeff A.; Yoakim, Christiane; Bonneau, Pierre R.; Bös, Michael; Cordingley, Michael G.; Déziel, Robert; Doyon, Louise; Duan, Jianmin; Garneau, Michel; Guse, Ingrid; Landry, Serge; Malenfant, Eric; Naud, Julie; Ogilvie, William W.; Thavonekham, Bounkham; Simoneau, Bruno


Book ID
126021777
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
152 KB
Volume
48
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Pyrimidine Thioethe
✍ R. A. NUGENT; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito