Novel 8-Substituted Dipyridodiazepinone Inhibitors with a Broad-Spectrum of Activity against HIV-1 Strains Resistant to Non-nucleoside Reverse Transcriptase Inhibitors
✍ Scribed by O'Meara, Jeff A.; Yoakim, Christiane; Bonneau, Pierre R.; Bös, Michael; Cordingley, Michael G.; Déziel, Robert; Doyon, Louise; Duan, Jianmin; Garneau, Michel; Guse, Ingrid; Landry, Serge; Malenfant, Eric; Naud, Julie; Ogilvie, William W.; Thavonekham, Bounkham; Simoneau, Bruno
- Book ID
- 126021777
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 152 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito
DNA primer/template complex that is needed to obtain a complete view of the NcRTIs mechanism of action.