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Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action

✍ Scribed by Séverine Freisz; Guillaume Bec; Marco Radi; Philippe Wolff; Emmanuele Crespan; Lucilla Angeli; Philippe Dumas; Giovanni Maga; Maurizio Botta; Eric Ennifar

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 687 KB
Volume: 49
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200905651

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## Abstract An extended spectrum of HIV‐1 reverse‐transcriptase (RT) mutations in HAART‐treated patients has been recently described. To verify the possible association of previously unreported RT mutations with a decrease of phenotypic susceptibility to nucleoside (NRTIs) and non‐nucleoside (NNRTI