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Protective effect of CV247 against cisplatin nephrotoxicity in rats

✍ Scribed by Mathe, C.; Szenasi, G.; Sebesteny, A.; Blazovics, A.; Szentmihalyi, K.; Hamar, P.; Albert, M.

Book ID
126507894
Publisher
SAGE Publications
Year
2013
Tongue
English
Weight
951 KB
Volume
33
Category
Article
ISSN
0960-3271

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r