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Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect

✍ Scribed by Rjiba-Touati, Karima; Ayed-Boussema, Imen; Bouaziz, Chayma; Belarbia, Anis; Azzabi, Awatef; Achour, Abdelatif; Hassen, Wafa; Bacha, Hassen

Book ID
121310864
Publisher
Informa plc
Year
2011
Tongue
English
Weight
774 KB
Volume
35
Category
Article
ISSN
0148-0545

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r