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Preparation of 5-fluorouracil-6-3H of high specific activity

✍ Scribed by Jíří Filip; František Vyšata

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
448 KB
Volume
5
Category
Article
ISSN
0022-2135

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✦ Synopsis

Isotopic exchange of hydrogen in a system of s~lvent-water-~H was used to prepare 5-Juoroorotic a ~i d -~H ( G ) which was decarboxylated and the hydrogen-3H removed from labile bonds to yield 5'-Juorouracil-6-3H. It was found in tracer experiments that a suitable solvent for the isotopic exchange of hydrogen was anhydrous dimethylformamide of dioxane. Water-3H of high specijic activity was prepared in these solvents by reduction of PtOz to Pt using carrierfree tritium. The specific activity of 5-JEuoro~raci1-6-~H was of the order of Cilmmole, the radiochemical purity was better than 96 %.

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