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Preparation of 6-azauracil-5-3H and 6-azauridine-5-3H of high molar activity

✍ Scribed by Jiri Filip; Jan Skoda; Hynek Hradec

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
404 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Catalytic reductive dehalogenation of 5‐bromo‐6‐azauracil with carrier‐free tritium led to 6‐azauracil‐5‐^3^ H of a molar activity of 19.0 Ci/mmole. The reaction conditions for the catalytic reductive dehalogenation were examined in tracer experiments. Microbial transformation was used for the preparation of 6‐azauridine‐5‐^3^ H from 6‐azauracil‐5‐^3^ H. 6‐Azauridine‐5‐^3^‐ H was prepared at a molar activity of 18.8 Ci/mmole. In both compounds the stability of tritium was investigated in an aqueous medium at 100°C.

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