The antidepressant alaproclate (IJ i s a selective i n h i b i t o r o f neuronal serotonin reuptake w i t h 1 ow aff i n i t y f o r other receptor sites. (2, 2-( [ 2,5-3H2]-4-chl orophenyl)-2-methyl-2-propyl 2-aminopropanoate) with high specific a c t i v i t y (38 C i / m o l ) was prepared by h
Purification of [3H]taurine of high specific activity
β Scribed by Robert E. Hruska; Ryan J. Huxtable; Henry I. Yamamura
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 216 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0003-2697
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π SIMILAR VOLUMES
The title compound has been prepared by two different approaches. The first involved a five-stage "hot" synthesis.where the tritiation step was selective debromination of a cyclic Fbromo-a-&unsaturated ketone. double bond was protected by formal aromatisation. this intermediate was determined by pro
The preparation of the 61-specific ligand 7-benzylidenenaltrexone (BNTX), labeled with tritium at high specific activity (14.4 Ciimmol) was prepared in 33% yield and >98% purity by the aldol condensation of high specific activity [15,1 6-3H]naltrexone with benzaldehyde at high dilution.
## Abstract Copperβcatalysed addition of ethyl diazoacetate to methyl scearolate (20 mmol scale) and subsequent saponification gave 9, 10βcarboxymethylene, 9βoctadecenoic acid in 67% yield. The letter was decarbonylated by treatment with HClO~4~/Ac~2~O in the cold (76 ΞΌmol scale) to give cycloprope