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The synthesis of [3H]cadralazine of high specific activity

✍ Scribed by Derek E. Brundish; Peter D. Kane

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
350 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The title compound has been prepared by two different approaches. The first involved a five-stage "hot" synthesis.where the tritiation step was selective debromination of a cyclic Fbromo-a-&unsaturated ketone. double bond was protected by formal aromatisation. this intermediate was determined by product. Cadralazine was also labelled in its side chain by reduction of the appropriate ketone with high specific activity sodium borotritide. labelled products had specific activities of 18 Ci/mmol and radiochemical purities of 90-96%. The The absolute structure of 3 H-PTNHR spectroscopy of its reduction Both

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