The antidepressant alaproclate (IJ i s a selective i n h i b i t o r o f neuronal serotonin reuptake w i t h 1 ow aff i n i t y f o r other receptor sites. (2, 2-( [ 2,5-3H2]-4-chl orophenyl)-2-methyl-2-propyl 2-aminopropanoate) with high specific a c t i v i t y (38 C i / m o l ) was prepared by h
Microscale synthesis of high specific activity 3H-nitroglycerin
β Scribed by J. J. Kawamoto; J. J. Brien; G. G. Marks; K. Nakatsu
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 265 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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The title compound has been prepared by two different approaches. The first involved a five-stage "hot" synthesis.where the tritiation step was selective debromination of a cyclic Fbromo-a-&unsaturated ketone. double bond was protected by formal aromatisation. this intermediate was determined by pro
labeled phosphoric a c i d (33P-H3P0t,). f r e e 33P-Ii3PO~ i d converted t o lead phosphate in t h e preaence of carrier by metathesis with l e a d oxide. Upon hydrogen reduction of t h e lead phosphate, elemental phosphorus is l i b e r a t e d and reacted with c h l o r i n e t o form phorphorua
## Abstract 4βHydroxyβ3β[3βoxoβ1β(3βbromophenyl)butyl]β2Hβ1βbenzopyranβ2βone (3β² βbromowarfarin) was synthesized and resolved into its enantiomers by formation of the __d__β10βcamphorsulfonate diastereoisomers, which were separated by liquid chromatography and hydrolyzed. The pure enantiomers were