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Synthesis and 3H NMR of 3H-alaproclate of high specific activity

✍ Scribed by Stefan Bengtsson; Lars Gawell; Thomas Högberg; Christer Sahlberg

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
310 KB
Volume
22
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

The antidepressant alaproclate (IJ i s a selective i n h i b i t o r o f neuronal serotonin reuptake w i t h 1 ow aff i n i t y f o r other receptor sites.

(2, 2-( [ 2,5-3H2]-4-chl orophenyl)-2-methyl-2-propyl 2-aminopropanoate) with high specific a c t i v i t y (38 C i / m o l ) was prepared by hydrogenolysis o f i t s 2,5d i b r m analogue z with tritiun gas.

step synthesis from 4-chlorotoluene. was v e r i f i e d by 3H NMR.

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