+)-Pisatin, the phytoalexin produced by pea (Pisum sativuni) tissues on fungal infection or by abiotic treatment, has been tritiated with high specific radioactivity (23.9 Ci.mnol-1) by treatment with n-butyllithium and T 2 0 . CCC 0362-4803/96/06057945 01996 by John Wiley & Sons, Ltd.
Synthesis of high specific radioactivity [3H]emodin
β Scribed by Aziz Hadj-Hamdri; Anne Vidal-Cros; Michel Gaudry; Franck Sobrio; Bernard Rousseau
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 245 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Emodin, a precursor of chrysophanol in the biosynthesis of cynodontin by Pyrenochaeta terrestris, has been tritiated with a high specific radioactivity (12.5 Ci/mmol) by hydrogenolysis of bromomethyl emodin.
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The title compound has been prepared by two different approaches. The first involved a five-stage "hot" synthesis.where the tritiation step was selective debromination of a cyclic Fbromo-a-&unsaturated ketone. double bond was protected by formal aromatisation. this intermediate was determined by pro