𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of high specific activity [15,16-3H2]buprenorphine

✍ Scribed by Ferenc Ötvös; Sándor Hosztafi; Csaba Simon; Géza Tóth

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
225 KB
Volume
36
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mrnol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.

📜 SIMILAR VOLUMES

Preparation of high specific activity [1
Preparation of high specific activity [15,16-3H]-7-benzylidenenaltrexone
✍ Anita H. Lewin; Pamela B. Lamb 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 136 KB 👁 1 views

The preparation of the 61-specific ligand 7-benzylidenenaltrexone (BNTX), labeled with tritium at high specific activity (14.4 Ciimmol) was prepared in 33% yield and >98% purity by the aldol condensation of high specific activity [15,1 6-3H]naltrexone with benzaldehyde at high dilution.

A convenient procedure for preparing nal
A convenient procedure for preparing naltrexone-15,16-3H2 and naloxone-15-3H of high specific activity
✍ George A. Brine; John A. Kepler 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 328 KB

## Abstract Mercury(II) oxide oxidation of naltrexone (1a) and naloxone (1b) gave 15,16‐didehydronaltrexone (4a) and 15,16 didehydronaloxone (4b). Subsequent reduction of 4a with tritium gas afforded naltrexone‐15,16‐^3^H~2~ having a‐specific activity of 15.3 Ci/mmole. Subsequent equilibration of 4

Synthesis of [16,16,17α-2H3] estradiol a
Synthesis of [16,16,17α-2H3] estradiol and [14α,15,15–2H3] estrone of high isotopic purity
✍ Ian J. Massey; Laszlo Tökés 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 410 KB

## Abstract The title compounds, each of high isotopic purity, were synthesized as internal standards for the mass spectral quantitation of estradiol and estrone. The [^2^H~3~] estradiol **3** was obtained from estrone (**1**) by alkaline H/^2^H exchange of the C‐16 protons and LiAl^2^LH~4~ reducti

The synthesis of [3H]cadralazine of high
The synthesis of [3H]cadralazine of high specific activity
✍ Derek E. Brundish; Peter D. Kane 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 350 KB

The title compound has been prepared by two different approaches. The first involved a five-stage "hot" synthesis.where the tritiation step was selective debromination of a cyclic Fbromo-a-&unsaturated ketone. double bond was protected by formal aromatisation. this intermediate was determined by pro