Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mrnol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidi
Preparation of [22,23-3H2]-dihydroavermectin B1a of high specific activity
โ Scribed by G. Toth; J. Kardos; A. Fodor; F. Sirokman
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 237 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
## Abstract A selective total synthesis of [11,12โ^3^H]โ9โ__cis__โretinoic acid 1 at a specific activity of 46 Ci/mmole is described. The alkyne 4, efficiently prepared in two steps from readily available starting materials, was partially reduced to 9,11โdiโ__cis__โretinoic acid 3 with both deuteri
## Abstract Mercury(II) oxide oxidation of naltrexone (1a) and naloxone (1b) gave 15,16โdidehydronaltrexone (4a) and 15,16 didehydronaloxone (4b). Subsequent reduction of 4a with tritium gas afforded naltrexoneโ15,16โ^3^H~2~ having aโspecific activity of 15.3 Ci/mmole. Subsequent equilibration of 4