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A preparation of high specific activity [11,12-3H]-9-cis-retinoic acid

✍ Scribed by Jotham W. Coe; Calvin R. Hawes; Patrick Towers

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
429 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A selective total synthesis of [11,12‐^3^H]‐9‐cis‐retinoic acid 1 at a specific activity of 46 Ci/mmole is described. The alkyne 4, efficiently prepared in two steps from readily available starting materials, was partially reduced to 9,11‐di‐cis‐retinoic acid 3 with both deuterium and tritium gas. Selective isomerization of 3 to 1 is discussed, as well as non‐selective direct conversions of 4 to 1.

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