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Preparation of 9-cis-retinoic acid [11,12-3H(N)] by photochemical isomerization

✍ Scribed by Marcia I. Dawson; Peter D. Hobbs; James F. Cameron; Sung W. Rhee

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
163 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

All‐trans‐Retinoic acid [11,12‐^3^H(N)] was photochemically isomerized using a fluorescent source to afford a mixture of isomeric retinoic acids, from which 9‐cis‐retinoic acid[11,12‐^3^H(N)] was isolated by reversed‐phase HPLC. The identity of 9‐cis‐retinoic acid [11, 12‐^3^H~2~] was confirmed by coinjection with the unlabeled acid.

📜 SIMILAR VOLUMES

A preparation of high specific activity
A preparation of high specific activity [11,12-3H]-9-cis-retinoic acid
✍ Jotham W. Coe; Calvin R. Hawes; Patrick Towers 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 429 KB

## Abstract A selective total synthesis of [11,12‐^3^H]‐9‐__cis__‐retinoic acid 1 at a specific activity of 46 Ci/mmole is described. The alkyne 4, efficiently prepared in two steps from readily available starting materials, was partially reduced to 9,11‐di‐__cis__‐retinoic acid 3 with both deuteri