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Preparation of high specific activity [15,16-3H]-7-benzylidenenaltrexone

✍ Scribed by Anita H. Lewin; Pamela B. Lamb

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 136 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199602)38:2<203::aid-jlcr828>3.0.co;2-d

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✦ Synopsis

The preparation of the 61-specific ligand 7-benzylidenenaltrexone (BNTX), labeled with tritium at high specific activity (14.4 Ciimmol) was prepared in 33% yield and >98% purity by the aldol condensation of high specific activity [15,1 6-3H]naltrexone with benzaldehyde at high dilution.

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