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Preparation of 18O-labelled nicotinamide

✍ Scribed by Magdalena Kołodziejska-Huben; Zbigniew Kamiński; Piotr Paneth

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
89 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A method of preparing ^18^O‐labelled nicotinamide, involving cyanopyridine, H~2~ ^18^O, and 1,1′3,3′‐tetramethylguanidine as a catalyst is described. The desired product is produced in 91% chemical yield and 97.5% isotopic incorporation. Copyright © 2002 John Wiley & Sons, Ltd.

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