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Synthesis of [17O]- and [18O]-labelled hypophosphate

✍ Scribed by Barry V. L. Potter

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
327 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

The preparation of 1 7 0 -and 180-labelled hypophosphate by oxidation of diphosphite (P2-P4 acid) with iodine-water is described. The 162 MHz NMR 31P(18O) isotope shift of 1 8 0 -l a b e l l e d hypophosphate is 2.42 Hz (0.0149 ppm), the relatively large value compared to l*O-pyrophosphate, 1.73 Hz (0.0107 ppm), being suggestive of an as yet unobserved 31P(18O) p-isotope shift of 1.38 Hz (0.009 ppm)

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