Synthesis of Concentrated 18O-Labelled Hydrogen Peroxide and of 2H-, 13C- and 18O-Labelled Peroxyformic Acid
โ Scribed by Guido Grassi; Markus Oldani; Alfred Bauder
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- German
- Weight
- 311 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0018-019X
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โฆ Synopsis
A method is described for the preparation of concentrated solutions (50โ70%) of ^18^Oโlabelled H~2~O~2~ in water. All singly ^2^Hโ, ^13^Cโ and ^18^Oโlabelled species of peroxyformic acid have been synthesized by the reaction of appropriately labelled formic acid and H~2~O~2~.
๐ SIMILAR VOLUMES
The preparation of 1 7 0 -and 180-labelled hypophosphate by oxidation of diphosphite (P2-P4 acid) with iodine-water is described. The 162 MHz NMR 31P(18O) isotope shift of 1 8 0 -l a b e l l e d hypophosphate is 2.42 Hz (0.0149 ppm), the relatively large value compared to l\*O-pyrophosphate, 1.73 Hz
## Abstract A facile method for the preparation of ^18^O labeled araโC and araโU is described. The method provides a means of incorporating ^18^O specifically at the 2โposition of the nucleobase. The site and level of label was established using mass spectrometry.
## Abstract The ifosfamide metabolite isophosphoramide mustard (IPM) was synthesized with isotopic enrichment at oxygen. Labelled benzaldehyde was made by exchange with isotopically enriched water (13.4 atom % ^17^0, 25.5 atom % ^18^0) and this was then reduced with sodium borohydride to give label
## Abstract A new procedure for the synthesis of methanesulfinyl chloride is described which involves chlorination of dimethyl disulfide with sulfuryl chloride in the presence of hexamethyldisiloxane. The use of ^18^Oโlabelled hexamethyldisiloxane in this reaction results in the formation of ^18^Oโ
## Abstract ^13^C labelled (1,2 and 1,12) and perdeuterated derivatives of 2โphenyl cyclododecanones, as precursors for labelled triplet flexible biradicals to probe magnetic isotope effects at the radical centers on the triplet decay dynamics, were synthesized. Isotopomers of 2โphenylcyclododecano