Preparation of 18F-labelled N-fluoropyridinium triflate
โ Scribed by Franz Oberdorfer; Evelyn Hofmann; Wolfgang Maier-Borst
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 289 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
BmMARY N-Fluoropyridinium triflate was labelled with 18P proceeding through N-trimethylsilylpyridinium triflate and [ 18F] F2 diluted to 1% in Ne. A typical experiment afforded this new fluorine-18 transfer reagent with up to 46% radiochemical yield. The specific activity of 18F-labelled N-fluoropyridinium trif late was determined by iodometric titration to be in the range of 4 ~1 0 ' ~ mq/Bq (1.5 mg/mci i 1.67 -10'~ ci/rn) .
๐ SIMILAR VOLUMES
## 5-[18F] Fluorouracil was prepared by direct fluorination of uracil in acetic acid using [18F]F2 diluted in neon. The labelled product was obtained with a purity of 299% following preparative HPLC. Quality control consisted of two different and improved HPLC procedures combined with high resolut
## Abstract A method of preparing ^18^Oโlabelled nicotinamide, involving cyanopyridine, H~2~ ^18^O, and 1,1โฒ3,3โฒโtetramethylguanidine as a catalyst is described. The desired product is produced in 91% chemical yield and 97.5% isotopic incorporation. Copyright ยฉ 2002 John Wiley & Sons, Ltd.
## Abstract 2โ and 3โ[^18^F]fluorothiophene and 2โ and 3 [^18^F]fluoroโNโmethyl pyrrole have been obtained by the reaction of thiophene and Nโmethylpyrrole with molecular fluorine [^18^F]โF~2~ under carefully controlled conditions.