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Preparation of 18F-labelled 5-fluorouracil of very high purity

✍ Scribed by Franz Oberdorfer; Evelyn Hofmann; Wolfgang Maier-Borst

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
413 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

5-[18F]

Fluorouracil was prepared by direct fluorination of uracil in acetic acid using [18F]F2 diluted in neon. The labelled product was obtained with a purity of 299% following preparative HPLC. Quality control consisted of two different and improved HPLC procedures combined with high resolution NMR spectroscopy for analyzing directly the HPLC elution peaks. A final formulation contained typically 4.8.10' Bq 5-[ "F] f luorouracil with a specific activity of 1.14.

Ci/pM.

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