18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities
The synthesis of high radiochemical purity of 2-[18F]-fluoro-2-deoxy-D-glucose without the use of preparative hplc
β Scribed by James Z. Ginos; Robert French; Robert Reamer
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 423 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Two alternative routes to no-carrier-added synthesis of 2-deoxy-2-[ "F] f luoro-D-glucose (2-18FDG) involving nucleophilic displacements of methyl 3-0-benzyl-4,6-0-benzylidene-2-O-(trifluoromethanesulfonyl~-~-D-mannopyranoside (1) and l,6-anhydro-3,4-di-0-benzyl-2-O-(trifluoromethanesulfonyl)-~-D-ma
A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside (1) with aninopolyether Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-