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Preparation and purification of 7-Iodoclonazepam for use in Radioimmunoassay

✍ Scribed by C P Goddard; B Law; P A Mason; A H Stead

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
277 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

A method is described for the preparation and purification of 7-[ 1251] -1odoc1onazepam ( 5-(2-Chlorophenyl ) -2,3-Dihydro-7-[ 1251]-Iodo-1H-1,4-Benzodiazepin-2-one). The structure was confirmed by mass spectrometry using 7-[ 1271]iodoclonazepam prepared by the same method. to a benzodiaeepine antiserum. Although readily displaced by all the benzodiazepines commercially available in the UK, it is not displaced by structurally related nonbenzodiazepines except at very high concentrations. therefore be useful for the development of a screening radioimmunoassay (RIA) for benzodiazepines. 7-[1251]-Iodoclonazepam binds well 7-[ 12%] Iodoclonazepam should

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