✦ LIBER ✦

Synthesis of iodobuprenorphine for use in radioimmunoassay

✍ Scribed by L. Debrabandere; M. van Boven; P. Daenens

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 449 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310803

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✦ Synopsis

Abstract

The synthesis of [^125^I]iodobuprenorphine is described. This compound has been used as a tracer molecule in the development of a new radioimmunoassay for buprenorphine. The parameters that effect the direct iodination of buprenorphine using sodium [^127^I]iodide, in the presence of either chloramine‐T or Iodo‐Beads^®^, were previously studied. The structure of iodobuprenorphine was confirmed by mass spectrometry.

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