𝔖 Bobbio Scriptorium
✦   LIBER   ✦

3-[125I] Iodo-4-hydroxyphenobarbitone for use in radioimmunoassay

✍ Scribed by P A Mason; B Law

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
230 KB
Volume
19
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A method is described for the preparation of a barbiturate derivative, 3‐iodo‐4‐hydroxyphenobarbitone, labelled with [^125^I]iodine. The structure of the compound was confirmed by synthesis and purification of the [^127^]iodine derivative followed by mass spectral studies. The [^125^I]iodine labelled barbiturate has proved to be chemically stable and has been shown to bind to a barbiturate antiserum. It should, therefore, prove to be very useful for the development of a radioimmunoassay for barbiturates.

📜 SIMILAR VOLUMES

Preparation of 2-[125I] iodohistamine-la
Preparation of 2-[125I] iodohistamine-labelled Δ8-tetrahydrocannabinol-11-oic acid for use in cannabinoid radioimmunoassay
✍ B Law; P A Mason; A C Moffat; L J King 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 453 KB

## Abstract A simple method is described for the preparation of 2‐[^125^I]iodohistamine‐labelled Δ^8^‐tetrahydrocannabinol‐11‐oic acid with high specific activity for use in radioimmunoassay. This compound is produced in high yield and shows excellent radiochemical stability when stored at 4°C. The

Preparation of N(1-ethyl-2-pyrrolidyl-me
Preparation of N(1-ethyl-2-pyrrolidyl-methyl)2-methoxy-4-iodo-125I- 5-ethyl sulfonyl benzamide: A radioligand for the radioimmunoassay of sulpiride-related compounds
✍ Maria Teresa Cardoso; Philippe Pradelles 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 194 KB

## Abstract We describe the preparation of ^125^I labelling with a higher specific radioactivity of N(1‐ethyl ‐2‐pyrrolidyl‐methyl)2‐ methoxy ‐5‐ethyl sulfonyl benzamide, a potent biological analogue for sulpiride. The incorporation of iodine in the molecule was achieved by the substitution of arom

Radiolabelling optimization of 5-(4-[125
Radiolabelling optimization of 5-(4-[125I]-iodophenyl)-2,3 dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole or [125I]-iodo mazindol : A potential tool for spect explorations
✍ E. Galinier; J. E. Ombetta; Y. Frangin; J. Mertens; J. C. Besnard; D. Guilloteau 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 467 KB

## Abstract The radiolabelling of an iodinated analog of mazindol, 5‐(4‐[^125^I]‐iodophenyl)‐2,3‐dihydro‐5‐hydroxy‐5H‐imidazo[2,1‐a]isoindole, was performed in order to develop a potential tool for SPECT exploration of the presynaptic dopamine transporter in the human brain. Radiosynthesis was perf

Synthesis and purification of desmethylz
Synthesis and purification of desmethylzopiclone-N-{3-(4-hydroxy-3-[125I]-iodophenyl) propionamide}, a prosthetic derivative of zopiclone for use in immunoassay
✍ E. Mannaert; P. Daenens 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 227 KB

## Abstract Condensation of [^125^I]‐Bolton/Hunter reagent with N‐desmethylzopiclone lead to the title compound which was isolated and purified by normal phase HPLC, in combination with gamma counting detection. The introduction of the prosthetic group into the tracer precursor was proven by L‐SIMS