✦ LIBER ✦

Preparation of N(1-ethyl-2-pyrrolidyl-methyl)2-methoxy-4-iodo-125I- 5-ethyl sulfonyl benzamide: A radioligand for the radioimmunoassay of sulpiride-related compounds

✍ Scribed by Maria Teresa Cardoso; Philippe Pradelles

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 194 KB
Volume: 19
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580190914

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✦ Synopsis

Abstract

We describe the preparation of ^125^I labelling with a higher specific radioactivity of N(1‐ethyl ‐2‐pyrrolidyl‐methyl)2‐ methoxy ‐5‐ethyl sulfonyl benzamide, a potent biological analogue for sulpiride. The incorporation of iodine in the molecule was achieved by the substitution of aromatic amino groups via the diazo compound. Binding and immunological parameters of iodinated and tritiated tracers were compared.

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