✦ LIBER ✦
Preparation of 2-[125I] iodohistamine-labelled Δ8-tetrahydrocannabinol-11-oic acid for use in cannabinoid radioimmunoassay
✍ Scribed by B Law; P A Mason; A C Moffat; L J King
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 453 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A simple method is described for the preparation of 2‐[^125^I]iodohistamine‐labelled Δ^8^‐tetrahydrocannabinol‐11‐oic acid with high specific activity for use in radioimmunoassay. This compound is produced in high yield and shows excellent radiochemical stability when stored at 4°C. The radiolabelled cannabinoid has been shown to bind avidly to four different broadly specific cannabinoid antisera. It is the only [^125^I] labelled cannabinoid suitable for use in radioimmunoassay with such antisera.