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Polymorphisms in the Thymidylate Synthase Gene Predict Response to 5-Fluorouracil Therapy in Colorectal Cancer

✍ Scribed by Tara Beers Gibson; Carlos Becerra; Edward Chu


Book ID
119616922
Publisher
CIG Media Group, LP.
Year
2006
Tongue
English
Weight
111 KB
Volume
5
Category
Article
ISSN
1533-0028

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has