## Abstract Thymidylate synthase (TS) is the primary target of 5βfluorouracil (5βFU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5βFUβbased chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has
β¦ LIBER β¦
Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer
β Scribed by David J. Park; Jan Stoehlmacher; Wu Zhang; Denice Tsao-Wei; Susan Groshen; Heinz-Josef Lenz
- Book ID
- 106060654
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 35 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0179-1958
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## Abstract The published data about thymidylate synthase (TS) expression and its predictive value in advanced colorectal cancer (CRC) patients receiving fluoropyrimidineβbased chemotherapy seemed inconclusive. To derive a more precise estimation of the relationship, a metaanalysis was performed. S