Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity
β Scribed by Kawakami, Kazuyuki ;Ishida, Yoshinori ;Danenberg, Kathleen D. ;Omura, Kenji ;Watanabe, Go ;Danenberg, Peter V.
- Book ID
- 108582106
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2002
- Tongue
- English
- Weight
- 394 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Polymorphic variations may affect the rate of gene transcription, the stability of the mRNA, or the quantity and activity of the resulting protein. In this study we evaluated the association between the interleukin-1B C-31T, catechol-O-methyltransferase Val158Met, and thymidylate synthase (TS) 1494d
## Abstract Thymidylate synthase (TS) is the primary target of 5βfluorouracil (5βFU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5βFUβbased chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has