Loss of heterozygosity (LOH) was examined at 27 loci on chromosomes 3p, 6q, I Ip, 13q. 17 and X in 42 human ovarian tumors. LOH was detected in I 2 of 26 (46%) and 5 of I 2 (42%) informative cases at 2 chromosome 13q loci, D13S32 and D I3534 respectively. On chromosome Xp, tumor-specific allele loss
Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer
β Scribed by Haifeng Qiu; Jiezhi Zhu; Cunzhong Yuan; Shi Yan; Qifeng Yang; Beihua Kong
- Book ID
- 108586665
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 449 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1347-9032
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## Abstract ## BACKGROUND Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer. Two imprinted genes, paternally expressed 3 (__PEG3__) and aplasia Ras homologue member I (__ARHI__), are the most frequently downβregulated in ovarian cancers on gene ex