Sporadic breast cancers often show allelic losses on the long arm of chromosome 17. Since the BRCA1 gene lies at 17q21.1 and the TOC locus, associated with esophageal cancer, lies at 17q25.1, either gene could be the target of those losses. We examined both loci in 178 primary breast cancers, using
Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer
β Scribed by Luciane R. Cavalli; Rebecca B. Riggins; Antai Wang; Robert Clarke; Bassem R. Haddad
- Book ID
- 106378373
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 189 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta
TP53 abnormalities have been reported as an early event in the process of cellular transformation of human breast cancers, and involved in mammary-tumor evolution, from in situ to invasive disease. In this study, node-negative (N-) tumors were examined for TP53 allelic loss in relation to different
## Abstract DALβ1/4.1B (__EPB41L3__)is a member of the protein 4.1 superfamily, which encompasses structural proteins that play important roles in membrane processes via interactions with actin, spectrin, and the cytoplasmic domains of integral membrane proteins. __DALβ1/4.1B__ localizes within chr