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Frequent loss of heterozygosity on chromosomes Xp and 13q in human ovarian cancer

✍ Scribed by Teresa L. Yang-Feng; Shibo Li; Hong Han; Peter E. Schwartz

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 683 KB
Volume: 52
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910520414

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✦ Synopsis

Loss of heterozygosity (LOH) was examined at 27 loci on chromosomes 3p, 6q, I Ip, 13q. 17 and X in 42 human ovarian tumors. LOH was detected in I 2 of 26 (46%) and 5 of I 2 (42%) informative cases at 2 chromosome 13q loci, D13S32 and D I3534 respectively. On chromosome Xp, tumor-specific allele loss was observed in 9 out of I 5 informative cases (60%) at the ornithine transcarbamylase (OK) gene locus. Examination of 'To whom correspondence and reprint requests should be addressed.

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