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Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas

✍ Scribed by Wendy H. Raskind; Ernest U. Conrad; Mark Matsushita

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 631 KB
Volume: 16
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199606)16:2<138::aid-gcc8>3.0.co;2-0

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✦ Synopsis

Many tumors exhibit loss of heterozygosity (LOH) for polymorphic markers in regions of the genome that contain genes whose normal function can suppress tumor growth. Mapping of regions of LOH can help identify putative tumor suppressor loci that play a role in the pathogenesis of a disease. We evaluated I8 chondrosarcomas for LOH at I7 short tandem-repeat polymorphism loci on chromosome 10. Sixty-seven percent of the tumors (I 211 8) showed LOH for at least one marker and in most of these tumors the region of loss spanned all or large portions of the chromosome. By determining the smallest segment consistently involved, we identified a 7-1 2 cM critical region for LOH in the proximal long arm. This genomic region contains the RET oncogene, which has been implicated in the pathogenesis of multiple endocrine neoplasia types 2A and 2B, Hirxhsprung disease, and medullary and papillary thyroid carcinomas. LOH on chromosome arm IOq was found in early-stage chondrosarcomas and did not correlate with grade or prognosis. Inactivation or alteration of a gene located at this site may be an early event in the development of these tumors. Genes Chrornosorn Cancer 16: 138-143 (1996).

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