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Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

✍ Scribed by Li-Fu Hu; Gudny Eiriksdottir; Tatyana Lebedeva; Irina Kholodniouk; Andrei Alimov; Fu Chen; Yan Luo; Eugene R. Zabarovsky; Sigurdur Ingvarsson; George Klein; Ingemar Ernberg

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 720 KB
Volume: 17
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199610)17:2<118::aid-gcc7>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

We have examined I 7 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte D N A from the same patients. Ten polymorphic microsatellite markers were used between 3p I 3 and 3p26. Allelic IOU was observed in I 2 samples (70%). Two loci were most frequently affected D3S I067 (3p2 I . I -14.3) in 60% and D3S I 2 I 7 (3p 14.2-14. I ) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S I297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages. Genes Chromosom Cancer 17:118-126 (1996).

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